서상원 교수

(의과대학 신경과학, SAIHST겸직)

Impact Factor ('13) = 17.472          Citations = 96th Percentile          Field-Weighted Citation Impact = 5.96           



Alzheimers Dement. 2015 May;11(5):494-503.e3. doi: 10.1016/j.jalz.2014.04.521. Epub 2014 Jul 19. 

Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.

Ye BS¹, Seo SW², Kim GH³, Noh Y⁴, Cho H⁵, Yoon CW⁶, Kim HJ⁷, Chin J⁷, Jeon S⁸, Lee JM⁸, Seong JK⁹, Kim JS¹⁰, Lee JH¹¹, Choe YS¹², Lee KH¹², Sohn YH¹³, Ewers M¹⁴, Weiner M¹⁵, Na DL⁷.

 

Abstract

BACKGROUND:

We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.

METHODS:

Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition.

RESULTS:

PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy.

CONCLUSIONS:

Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions.

Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Amyloid; Atrophy; Cerebrovascular disease; Cognition; Cortical thickness; Hippocampus; Path analysis; Pittsburgh compound B

PMID:25048578[PubMed - indexed for MEDLINE]

(출처_PubMed)