1. Kor /
  2. Eng

  1. Kor /
  2. Eng

Major AchievementsFollowings are the major outstanding achievements of the SAIHST faculties

[서상원 교수] Alzheimer's & Dementia 2015 May;11(5):494-503.e3.
No 1
Date 2016/02/11

 

 

 

      

서상원 교수

(의과대학 신경과학, SAIHST겸직)

 

 

Impact Factor ('13) = 17.472          Citations = 96th Percentile          Field-Weighted Citation Impact = 5.96           



 

 2015 May;11(5):494-503.e3. doi: 10.1016/j.jalz.2014.04.521. Epub 2014 Jul 19. 

Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.

 

Abstract

BACKGROUND:

We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.

METHODS:

Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition.

RESULTS:

PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy.

CONCLUSIONS:

Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions.

Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Amyloid; Atrophy; Cerebrovascular disease; Cognition; Cortical thickness; Hippocampus; Path analysis; Pittsburgh compound B

PMID:25048578[PubMed - indexed for MEDLINE]

(출처_PubMed)

 

 

서상원 교수 연구소개     [프로필 보기] 

 

본 연구실은 치매에 대한 뇌 영상 연구와 뇌 노화에 대한 역학 연구를 수행하고 있으며, 이들 자료들을 다양한 최신 통계 기법들을 이용해 분석하고 있으며, 지금까지 150여편의 논문을 SCI(E) 저널에 발표하고 있음. 특히, 알츠하이머병과 관련한 MRI 및 분자 뇌영상, 혈관성 치매와 관련된 MRI 뇌영상 마커들을 이용해 혈관성 병변과 관련한 알츠하이머병에 대한 다양한 뇌 영상연구를 하고 있으며, 이 분야에서는 세계적으로 가장 경쟁력 있는 기관으로 인정을 받고 있음. 국내 다양한 뇌 영상 분석 연구실과 긴밀한 협력 관계를 유지하고 있으며, 역학 및 통계 지원 팀과의 다양한 공동연구를 통해 기존에 시행되기 힘들었던 분석들을 시도함으로써 이전에는 보여주기 힘들었던 기전들을 밝히고 있음. 또한, 5000여례의 뇌영상 자료들을 이용해 뇌 노화를 예방하는 인자와 촉진시키는 인자들을 밝히고 한국인의 표준 뇌 모델 및 이들에 대한 예측모델을 만들고 있음.  

 

 

 

 

 

 

 

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