| Jong Wook Chang / Ph.D. |
Name : Jong Wook Chang Ph.D.
Department : SAIHST
Title : Professor
Office : 삼성서울병원 미래의학관 지하3층
E-mail : changjw@skku.edu, jongwook.chang@samsung.com
Homepage : https://www.cgtlabskku.com/
Lab. title : Lab of Cell and Gene Therapy
Related Department : Department of Health Sciences and Technology,Department of Medical Device Management and Research
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■ Careers 1999-2005 Ph.D. GIST 2005-2007 Postdoctoral Researcher, KIST Former Research Director, MEDIPOST Co., Ltd. Present GMP Director & Professor, Samsung Medical Center Present 24’ Industry-Academic Cooperation Committee Chair Korean Society for Stem Cell Research Present ENCell. Co. ltd CEO (https://encellinc.com/main/) Present International Journal of Stem Cells, Associate Editor Present Professor, Sungkyunkwan University, SAIHST ■ Lap Introduction Our lab has been focused on developing advanced cell & gene therapy products as well as GMP manufacturing platforms. We are specifically focused on culturing mesenchymal stem cells (MSCs) isolated from human Wharton’s jelly and/or placenta as a therapeutic candidate to treat nervous and neuromuscular diseases. It is widely accepted among the scientific community that MSCs exert therapeutic effects by secreting various proteins to the lesion site. Such biological properties and therapeutic mechanisms of MSCs have laid the foundation to initiate the commercialization of cell therapy. One of our major objectives is to investigate the mechanisms involved in the therapeutic properties of MSCs specifically in relation to neuromuscular diseases which will play a fundamental role in the development of next-generation cell-therapies. We have a wide range of interests spanning from stem cell therapy, anticancer immunotherapy, gene therapy, and development of advanced cell & gene therapy products for the treatment of incurable diseases. Current and advanced cell / gene therapy products must adhere to GMP standards. Thus, it is imperative to develop novel technologies required for the manufacture and quality control of these products. It is also of utmost importance to continually support the training of GMP professionals. ■ Keywords: Advanced Regenerative Medicine and Advanced Biological Products, Stem cell therapy, Gene therapy, Neuromuscular diseases, GMP ■ Selected Publications (2019 ~ Present) 1. Song JH, Kim SJ, Kwon S, et al. Nervonic acid improves fat transplantation by promoting adipogenesis and angiogenesis. Int J Mol Med. 2024;54(6) doi:10.3892/ijmm.2024.5432
2. Lee EJ, Kim SJ, Jeon SY, et al. Glutaminase-1 inhibition alleviates senescence of Wharton's jelly-derived mesenchymal stem cells via senolysis. Stem Cells Transl Med. 2024;13(9):873-885. doi:10.1093/stcltm/szae053
3. Lee NK, Chang JW. Manufacturing Cell and Gene Therapies: Challenges in Clinical Translation. Ann Lab Med. 2024;44(4):314-323. doi:10.3343/alm.2023.0382
4. Ngo D, Lee J, Kwon SJ, Park JH, Cho BH, Chang JW. Application of Deep Neural Networks in the Manufacturing Process of Mesenchymal Stem Cells Therapeutics. Int J Stem Cells. 2024 doi:10.15283/ijsc24070
5. Kim SJ, Kwon S, Chung S, et al. Nervonic Acid Inhibits Replicative Senescence of Human Wharton's Jelly-Derived Mesenchymal Stem Cells. Int J Stem Cells. 2024;17(1):80-90. doi:10.15283/ijsc23101
6. Sung DK, Kim H, Park SE, et al. A New Method of Myostatin Inhibition in Mice via Oral Administration of Lactobacillus casei Expressing Modified Myostatin Protein, BLS-M22. Int J Mol Sci. 2022;23(16) doi:10.3390/ijms23169059
7. Kim SJ, Park SE, Jeong JB, et al. Wharton's Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential. Stem Cells Int. 2022;2022:4711499. doi:10.1155/2022/4711499
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