| KIM, HYEON HO / Ph.D. |
Name : KIM, HYEON HO Ph.D.
Department : SAIHST
Title : Associate Professor
Office : Samsung Comprehensice Cancer Center B4-118
E-mail : hyeonhkim@skku.edu
Homepage :
Lab. title : Laboratory of Posttranscriptional Gene Regulation
Related Department : Department of Health Sciences and Technology
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■ Careers Education 1995 Bs, Korea University, Department of Biotechnology 1997 Ms, Korea Univeristry, Department of Biotechnology 2002 PhD, Graduate School of Life Science and Biotechnology, Korea University Careers 2002-2005 Post-doc, Seoul National University Hospital 2005-2010 Visiting Fellow, National Institute on Aging (NIA/NIH) Present Assistant Professo, Sungkyunkwan University, SAIHST ■ Research Summary Our research theme is understanding how genes are posttranscriptionally regulated. Genes are regulated by two ways; transcriptional and posttranscriptional. Posttranscriptional gene regulation is performed by binding of RNA-binding proteins or microRNA to non-translated region (UTR). We have been interested in posttranscriptional regulation of genes which are associated cancer development and metastasis. We recently investigate (1) regulation of cancer-related genes (PDCD4, PTEN) by RNA-binding proteins (2) cooperative gene regulation by RNA-binding proteins and microRNAs (3) control of microRNA biogenesis by RNA-binding proteins (4) functions of metastatic tissue-specific genes and microRNAs using Xenograft model. Finally we hope our results provide a new paradigm for cancer therapy and contribute to human health. ■ Keyword Posttranscriptional gene regulation, Cancer development, Metastasis, RNA-binding proteins, miRNAs ■ Selected Publications 1. Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, Gleichmann M, Mughal MR, Martindale JL, Yang X, Worley PF, Mattson MP, Gorospe M. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010 May 16. 17:732-9. 2. Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, and Gorospe M. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev. 2009 Aug 1;23(15):1743-8. 3. Kim HH, Yang X, Kuwano Y, and Gorospe M. Modification at HuR(S242) alters HuR localization and proliferative influence. Cell Cycle 2008 Nov 1;7(21):3371-77. 4. Kim HH and Gorospe M. Phosphorylated HuR shuttles in cycles. Cell Cycle 2008 Oct 15;7(20):3124-26. 5. Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr., Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, and Gorospe M. Nuclear HuR accumulation through phosphorylation by cdk1. Genes Dev. 2008 Jul 1;22(13):1804-15. |
