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우수성과SAIHST 구성원의 언론보도내용 및 수상내역, 각 연구분야의 우수 학술지에 게재된 논문 등 우수한 성과들을 소개합니다.

[이기영 교수/ 우수논문] Clinical and Translational Medicine, 12 Sep 2022
No -1
작성자 관리자
등록일 2022/10/17

 

 


IF: 11.492

 

 


Clinical and Translational Medicine,  2022 Sep;12(9):e1050.doi: 10.1002/ctm2.1050.

 

CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells

Mi-Jeong KimJi Su LeeJi Young KimBongkum ChoiJuhee SonYoon MinSoo-Kyung JeongDuk-Hwan KimJoo Sang LeeEunyoung ChunKi-Young Lee

 

Abstract

Dear Editor,

Cereblon (CRBN) has been identified as a primary target of immunomodulatory drugs in multiple myeloma.1 Herein, for the first time, we demonstrate that CRBN expression is functionally involved in lung cancer progression through the regulation of autophagy by toll-like receptor (TLR)2, TLR4 and TLR7. TLR signalling is associated with the induction of autophagy and plays a pivotal role in the progression and pathogenesis of lung cancer.2 Our study suggests that CRBN can be a potent prognostic marker for lung cancer and provides important implications in clinical and translational lung cancer biology

 

 

 

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