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우수성과SAIHST 구성원의 언론보도내용 및 수상내역, 각 연구분야의 우수 학술지에 게재된 논문 등 우수한 성과들을 소개합니다.

[이기영 교수/ 우수논문] Clinical and Translational Medicine, 12 Jun 2022
No 1
작성자 관리자
등록일 2022/10/17

 

IF: 11.492 





 

Clinical and Translational Medicine, 2022 Jun;12(6):e896.doi: 10.1002/ctm2.896.

 

Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy induction


Ji Young Kim Mi-Jeong Kim Ji Su Lee Juhee Son Duk-Hwan Kim Joo Sang Lee Soo-Kyung Jeong Eunyoung Chun Ki-Young Lee 


Abstract

Dear Editor,

Lung cancer progression is regulated by various extrinsic factors derived from tumour microenvironment as well as intrinsic factors.1 Recent studies have shown that toll-like receptors (TLRs) are expressed in lung cancers, suggesting that TLRs may be implicated in lung cancer progression.2,3 Although several studies have shown that stratifin (SFN, 14-3-3 sigma) facilitated lung cancer development and progression,46 the molecular and cellular mechanisms by which SFN is functionally involved in lung cancer progression, and the role of SFN in lung cancer progression in response to extrinsic stimulation, such as TLR agonist, are largely unknown. Here, we show that SFN expression is remarkably up-regulated in lung cancer tissues through The Cancer Genome Atlas (TCGA) data and primary nonsmall cell lung cancers (n = 31 of our cohort patients) analysis, and SFN positively regulates lung cancer progression through the autophagy induction by facilitating TRAF6- Vps34-BECN1 complex in response to an extrinsic TLR4 agonist


 

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