Nature Human Behaviour. 2022 May 19. doi: 10.1038/s41562-022-01343-5. Online ahead of print.
Shared genetic architectures of subjective well-being in East Asian and European ancestry populations
Soyeon Kim, Kiwon Kim, Mi Yeong Hwang, Hyunwoong Ko, Sang-Hyuk Jung, Injeong Shim, Soojin Cha, Hyewon Lee, Beomsu Kim, Joohyun Yoon, Tae Hyon Ha, Doh Kwan Kim, Jinho Kim, Woong-Yang Park, Aysu Okbay, Bong-Jo Kim, Young Jin Kim, Woojae Myung & Hong-Hee Won
Abstract Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.
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