Faulty List At SAIHST, we have faculties from various backgrounds such as ; basic science, clinical medicine, pharmacology, engineering, business etc. SAIHST is always open for future competent faculties to lead biomedical science.
| 연구실 / |
Name : 연구실
Department :
Title :
Campus :
Office : Laboratory of Epigenetic Transcriptional Regulation
E-mail : jeongkim@skku.edu
Homepage :
Lab. title :
Related Department : Department of Health Sciences and Technology
Print
|
|
■ Research Objectives
The research focus of our laboratory is to investigate molecular mechanisms of transcriptional regulator (transcription factors and coregulators)-mediated tumorigenesis and cancer progression. We have discovered and characterized several novel transcriptional coregulators, which interact with the activated transcription factors, facilitate transcription complex formation and long-range enhancer-promoter communication, and establish active and repressive epigenetic states of chromatin. The study of coregulators including epigenetic modifiers has recently become one of the most exciting and fast-moving areas of epigenetic gene regulation fields; it provides an exciting opportunity to extend our understanding of the mechanisms of transcriptional regulation in cancer cells. A more complete understanding of how transcription factors and coregulators regulate gene expression should provide new insights into cancer epigenetics and suggest new strategies for cancer therapy. ■ Research Keywords: Transcriptional regulation, Transcription factors, Coregulators, Histone modifications, Epigenetics, Prostate cancer, Breast cancer, Colon cancer ■ Ongoing Research Projects 1) Roles of histone acetylation and methylation in epigenetic regulation of gene expression and cancer progression 2) Mechanism of AR variant AR-V7-mediated CRPC progression and development of AR-V7 targeting drugs 3) Preclinical and mechanistic studies of bruceantin as an anti-advanced castration-resistant prostate cancer agent 4) Deciphering the Estrogen Receptor Hinge Post-Translational Modification (PTM) and Mutation Codes in Endocrine-Resistant Breast Cancer and Investigating the Role of DBC1 as a Key Regulator of ER ■ Ongoing Lab: 02-2148-7280 Email: jeongkim@skku.edu |