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[박상언/융합] 제1저자 Neuroreport. 2016 Mar 2;27(4):235-41.
등록일 2016/03/14
조회수 3,592

 

 

 

박상언 / 지도교수: 나덕렬

(융합의과학과 석박통합과정)

 

 

2016 Mar 2;27(4):235-41. doi: 10.1097/WNR.0000000000000526.

Distribution of human umbilical cord blood-derived mesenchymal stem cells in the Alzheimer's disease transgenic mouse after a single intravenous injection.

 

Abstract

The aim of this study was to track the migration of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered through a single intravenous injection and to observe the consequential therapeutic effects in a transgenic Alzheimer's disease mouse model. Ten-month-old APP/PS1 mice received a total injection of 1×10 cells through the lateral tail vein and were killed 1, 4, and 7 days after administration. On the basis of immunohistochemical analysis, hUCB-MSCs were not detected in the brain at any of the time points. Instead, most of the injected mesenchymal stem cells were found to be distributed in the lung, heart, and liver. In terms of the molecular effects, statistically significant differences in the amyloid β protein, neprilysin, and SOX2 levels were not observed among the groups. On the basis of the results from this study, we suggest that single intravenously administered hUCB-MSCs are not delivered to the brain and also do not have a significant influence on Alzheimer's disease pathology.

 

PMID:26752148 [PubMed - in process]

 

 

(출처_PubMed)

 

 

 

 

나덕렬 교수 연구소개    [프로필 보기]

 

 

삼성서울병원 인지신경학·치매 팀은 임상팀과 줄기세포 팀으로 구성되어 있다. 임상팀은 나덕렬 교수, 서상원 교수, 김희진 임상전임강사, 임상강사 및 연구강사 5~6명(신경과 전문의), 신경심리학자 2명 (진주희 박사, 이병화 박사) 및 신경심리사 3명, 언어병리학자 (서미경 박사) 1명, 연구원 등으로 구성되어 있다. 줄기세포 팀은 박사연구원 1명, 대학원생 5명, 연구원 4명으로 구성되어 있다. 본 연구팀은 크게 4개의 연구주제를 가지고 있다. 

1. 알츠하이머병의 줄기세포 치료 - Mesenchymal stem cell을 다양한 경로를 통하여 뇌에 주입하여 알츠하이머병 치료제를 개발하는 방법을 모색하고 있고, 알츠하이머병에 특화된 차세대 줄기세포를 만드는 노력을 하고 있으며, IPSC를 통한 질병모델 구축과 병리기전 연구를 하고 있다.
2. 줄기세포 반복투여 장치 개발: implantable device를 이용하여 수술을 한 후에는 피부 절개를 하지 않고 줄기세포를 반복투여하는 장치를 개발 중이다. 
3. Brain sensor/stimulator개발 - 신소재 초소형 다기능 sensor/stimulator를 개발하여 뇌전증, 파킨슨병, 치매 등에 적용하려는 연구를 진행 중이다. 
4. Neuroimaging연구 - 정상인, 경도인지장애, 치매 환자를 대상으로 MRI, PET를 촬영하여치매의 조기진단과 치료효과 분석에 사용하고 있다. 
5. cognitive training - 인간의 인지기능을 향상시키는 여러 가지 방법을 모색하고 있다. 궁극적으로 brain fitness center를 구축하고자 한다. 

이들 목표를 성취하기 위해 삼성서울병원 줄기세포재생의학센터의 장종욱 교수, 메디포스트, S&G biotech, 동아치매센터, MI Tech, 포항공대 산업공학과 유희천 교수, 한양대 의용생체공학과의 이종민 교수, 고려대학교의 성준경교수, 이상훈교수, 삼성서울병원 영상의학과 김성태, 이정희 교수, 핵의학과 최연성, 이경한 교수팀과 각 분야에서 공동연구를 진행 중이며, 1년에 15편 정도의 논문을 SCI등재 잡지에 게재하고 있다.   

 

 



 

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