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Clinical and Translational Medicine, 2022
Jun;12(6):e896.doi: 10.1002/ctm2.896.
Stratifin (SFN) regulates lung
cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy
induction
Ji Young Kim , Mi-Jeong Kim , Ji Su Lee , Juhee Son , Duk-Hwan Kim , Joo Sang Lee , Soo-Kyung Jeong , Eunyoung Chun , Ki-Young Lee
Abstract
Dear
Editor,
Lung
cancer progression is regulated by various extrinsic factors derived from
tumour microenvironment as well as intrinsic factors.1 Recent studies have
shown that toll-like receptors (TLRs) are expressed in lung cancers,
suggesting that TLRs may be implicated in lung cancer progression.2,3
Although several studies have shown that stratifin (SFN, 14-3-3 sigma)
facilitated lung cancer development and progression,4–6 the molecular and cellular mechanisms by which SFN is
functionally involved in lung cancer progression, and the role of SFN in lung
cancer progression in response to extrinsic stimulation, such as TLR agonist,
are largely unknown. Here, we show that SFN expression is remarkably
up-regulated in lung cancer tissues through The Cancer Genome Atlas (TCGA)
data and primary nonsmall cell lung cancers (n = 31 of our cohort patients) analysis,
and SFN positively regulates lung cancer progression through the autophagy
induction by facilitating TRAF6- Vps34-BECN1 complex in response to an
extrinsic TLR4 agonist
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