교수진 및 연구실 소개SAIHST에는 기초의학, 임상의학, 자연과학, 약학, 공학, 경영대학 등 Health Science와 관련된 다양한 분야를 전공한 교수진이 참여하고 있습니다.
미래의과학을 선도할 역량있는 교수의 참여를 기다립니다.
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Structural and Chemical Biology LAB/김경규 교수 E-mail : kyeongkyu@skku.edu Homepage : http://scbl.skku.edu 참여학과 : 융합의과학과 인쇄하기 |
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■ Research objective
Our main research interests are structural and functional elucidation of the key biological macromolecules using X-ray crystallography and cryo EM, and their intervention to develop novel drugs targeting cancer and infectious diseases. In addition, we are working on chemical-based cell conversion for understanding the biomedical background of cell fate and its clinical application for incurable diseases. ■ Research interests 1)Noncanonical DNAs: Structures, functions and their mutations in diseases A variety of DNAs and RNAs in cells have not been defined by Watson-Crick rules , but form non-B-DNA structures with non Watson-Crick base pairs, which are described as non-canonical DNAs. Non-canonical DNAs and RNAs play important roles in controlling various cellular processes including transcription and translation. Accordingly, mutations in noncanonical DNAs are highly relevant to the uncontrolled cell division such as cancer. We are working on elucidating their structure, function and their implication in diseases. 2)Chemical based direct cell conversion, a new platform for regeneration medicine Stem cell therapy is considered to be the most promising tools for treating the incurables diseases such as spinal cord injury and myocardial infarction. However due to the side effect such as causing cancer, clinical application of stem cells is limited. To solve this issues, therapeutic cells can be made from the somatic cells instead of stem cellby the “direct cell conversion”. We are developing novel methods for direct cell conversion and applying cells successfully for treating various incurable diseases as a new platform for regenerative medicine. 3)Understand antimicrobial resistance and developing new antibiotics Antimicrobial resistance (AMR) has become a serious threat to human health because resistance to the various antibiotics available eventually causes no way to treat disease caused by the bacterial infection. Therefore, developing new potent antibiotics or an alternative ‘Resistance-resistant antibacterial therapy’ is necessary to overcome AMR infections. We are working on elucidating the mechanism of AMR development and developing new therapeutics against AMR infection. ■ Contact kyeongkyu@skku.edu |