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우수성과SAIHST 구성원의 언론보도내용 및 수상내역, 각 연구분야의 우수 학술지에 게재된 논문 등 우수한 성과들을 소개합니다.

[박웅양 교수/ 우수논문] Nature Communications. 2017 May
No 44
작성자 관리자
등록일 2017/07/10



박웅양 교수

(SAIHST 융합의과학과, 디지털헬스학과)



Impact Factor ('16) = 12.124



Nat Commun. 2017 May 5;8:15081. doi: 10.1038/ncomms15081.



Single-cellRNA-seqenablescomprehensivetumour and immunecellprofiling in primarybreastcancer.

Woosung Chung, Hye Hyeon Eum, Hae-Ock Lee, Kyung-Min Lee, Han-Byoel Lee, Kyu-Tae Kim, Han Suk Ryu, Sangmin Kim,Jeong Eon Lee, Yeon Hee Park, Zhengyan Kan, Wonshik Han and Woong-Yang Park.



Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of heterogeneous tumour cells along with neighbouring stromal and immune cells. Here we adopt this powerful approach to breast cancer and analyse 515 cells from 11 patients. Inferred copy number variations from the single-cell RNA-seq data separate carcinoma cells from non-cancer cells. At a single-cell resolution, carcinoma cells display common signatures within the tumour as well as intratumoral heterogeneity regarding breast cancer subtype and crucial cancer-related pathways. Most of the non-cancer cells are immune cells, with three distinct clusters of T lymphocytes, B lymphocytes and macrophages. T lymphocytes and macrophages both display immunosuppressive characteristics: T cells with a regulatory or an exhausted phenotype and macrophages with an M2 phenotype. These results illustrate that the breast cancer transcriptome has a wide range of intratumoral heterogeneity, which is shaped by the tumour cells and immune cells in the surrounding microenvironment.







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